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The UMass protein crystallography home page is at xtal.biochem.umass.edu
This journal club is organized by Scott Garman, Jeanne Hardy, and Karsten Theis.We share a common interest in structural biology, including X-ray crystallographic techniques. Our labs are all located on the 10th floor of Lederle Tower, along with the X-ray diffraction facility.
If you are looking for the home page of the UMass X-ray diffraction facility, you can find it here.
If you are looking for Karsten Theis' home page, it is here, while Scott Garman's home page is here, and Jeanne Hardy's is here.
Journal Club meets Thursdays at 8:20am in 1020 LGRT (Pinkham room). Every week, we will have one discussion leader who will ask for multiple volunteers to present selected data (figures or tables).
Date |
Topic |
Presentation leader |
Readings and links |
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5 Feb 09 |
AAA ATPase | Cassidy | paper |
Jason M. Davies, Axel T. Brünger, & William I. Weis "Improved Structures of Full-Length p97, an AAA ATPase: Implications for Mechanisms of Nucleotide-Dependent Conformational Change" Structure (2008) 16:715 |
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12 Feb 09 |
Opsin |
Sravanti |
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Patrick Scheerer, Jung Hee Park, Peter W. Hildebrand, Yong Ju Kim, Norbert Krauß, Hui-Woog Choe,
Klaus Peter Hofmann, & Oliver P. Ernst "Crystal structure of Opsin in its G-protein-interacting conformation" Nature (2008) 455:497 |
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19 Feb 09 |
Fe2+ Dioxygenase | Nitai | paper, supplemental |
Elena G. Kovaleva and John D. Lipscomb "Crystal Structures of Fe2+ Dioxygenase Superoxo, Alkylperoxo, and Bound Product Intermediates" Science (2007) 316:453 |
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26 Feb 09 |
General discussion | Karsten | |
Murphy & Theis methods paper |
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5 Mar 09 |
APOBEC | Kristen | paper, supplemental |
Lauren G. Holden, Courtney Prochnow, Y. Paul Chang, Ronda Bransteitter, Linda Chelico, Udayaditya Sen, Raymond C. Stevens, Myron F. Goodman, & Xiaojiang S. Chen "Crystal structure of the anti-viral APOBEC3G catalytic domain and functional implications" Nature (2008) 456:121 |
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12 Mar 09 |
Seneca Valley Virus | Nilima | paper |
Sangita Venkataraman, Seshidhar P. Reddy, Jackie Loo, Neeraja Idamakanti, Paul L. Hallenbeck, and Vijay S. Reddy "Structure of Seneca Valley Virus-001: An Oncolytic Picornavirus Representing a New Genus" Structure 16, 1555 |
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Spring Break |
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26 Mar 09 |
Complement C3b | Sam | paper, supplemental (.doc), communication |
A. Abdul Ajees, K. Gunasekaran, John E. Volanakis, Sthanam. V. L. Narayana, Girish J. Kotwal & H. M. Krishna Murthy "The structure of complement C3b provides insights into complement activation and regulation" Nature (2006) 444:221 |
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2 Apr 09 |
Aminoacyl-tRNA synthetase | Yady | paper |
Timothy L. Bullock, Annia Rodríguez-Hernández, Eleonora M. Corigliano, and John J. Perona "A rationally engineered misacylating aminoacyl-tRNA synthetase" PNAS (2008) 105:7428 |
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9 Apr 09 |
LDL Receptor | Nat | paper 1, paper 2 |
Gabby Rudenko, Lisa Henry, Keith Henderson,
Konstantin Ichtchenko, Michael S. Brown,
Joseph L. Goldstein, Johann Deisenhofer "Structure of the LDL Receptor Extracellular Domain at Endosomal pH" Science (2002) 298:2353 Hyock Joo Kwon, Thomas A. Lagace, Markey C. McNutt, Jay D. Horton, and Johann Deisenhofer "Molecular basis for LDL receptor recognition by PCSK9" PNAS (2008) 105:1820 |
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16 Apr 09 |
Ube2g2 | Ivan | paper, supplemental |
Wei Li, Daqi Tu, Lianyun Li, Thomas Wollert, Rodolfo Ghirlando, Axel T. Brunger, and Yihong Ye "Mechanistic insights into active site-associated polyubiquitination by the ubiquitin-conjugating enzyme Ube2g2" PNAS (2009) 108:3722 |
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23 Apr 09 |
Mh-p37 methods | Melisa | paper |
Katherine H. Sippel, Arthur H.
Robbins, Robbie Reutzel, John
Domsic, Susan K. Boehlein,
Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Charles J. Rosserc and Robert McKenna, "Structure determination of the cancer-associated Mycoplasma hyorhinis protein Mh-p37" ActaCryst (2008) D64:1172 |
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30 Apr 09 |
classic HLA papers | Scott | paper1, paper2, N&V |
Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, & Wiley DC "Structure of the human class I histocompatibility antigen, HLA-A2" Nature (1987) 329:506-512 Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, & Wiley DC "The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens" Nature (1987) 329:512-518 |
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7 May 09 |
In-house sulfur SAD | Daniel | paper |
Jie Nan, Yanfeng Zhou, Cheng Yang, Erik Brostromer, Ole Kristensen, and Xiao-Dong Su "Structure of a fatty acid-binding protein from Bacillus subtilis determined by sulfur-SAD phasing using in-house chromium radiation"ActaCryst (2009) D65:440 |