UMass Amherst
 

  Biochem 523: General Biochemistry

Fall 2014
Goessmann 64
MWF
11:15-12:05


Instructors:

Alejandro P. Heuck (apheuck@biochem.umass.edu)
   
TA hours Will be scheduled before each exam

Today is


aGal
Class Day Date Topics

Reading
PC = Pratt & Cornely

Links Covered
Notes
Lec 1

W

3 Sep

Course Description

 

Course info

Q1, E1

 

Lec 2

F

5 Sep

Overview

PC 1-1 to 1-4

Movie Lec 2 pdf

Q1, E1

First practice homework posted

Lec 3

M

8 Sep

Aqueous Chemistry

PC 2-1 to 2-4

Lec 3 after pdf

Q1, E1

 

Lec 4

W

10 Sep

Nucleic Acid Structure

PC 3-1, 3-2

Movie Lec 4 after pdf

Q1, E1

The double helix Movie

Lec 5

F

12 Sep

Protein Structure 1

PC 4-1 to 4-2

Lec 5 after pdf

Q1, E1

For TA session info see Announcements

Lec 6

M

15 Sep

Quiz 1; Protein Structure 2

Study guideQuiz1 pdf

Lec 6 after pdf

E1

Last day Add or drop

Lec 7

W

17 Sep

Protein Folding

PC 4-3, 4-4

Lec 7 after pdf Quiz 1 key

E1

SEC movie IEC movie

Lec 8

F

19 Sep

Protein Analysis

PC 4-5

Lec 8 aft pdf Lecture flash

E1

 

Lec 9

M

22 Sep

Myoglobin/Hemoglobin 1 PC 5-1

Lec 9 after pdf

E1

 

Lec 10

W

24 Sep

Myoglobin/Hemoglobin 2  

Lec 10 after pdf

Q2, E2

Seminar on Anthrax link

Rev

F

26 Sep

Review and Problems

 

Review pdf

 

 

 

M

29 Sep

Exam 1: 7-9pm

Bartlett 65

 

Study guide pdf

 

Exam 1 average was 83

StDev 13

Lec 11

W

1 Oct

Structural/motor Proteins

PC 5-2 to 5-3

Lec11 aft pdf Lecture flash

Q2, E2

Exam 1 key

Lec 12

F

3 Oct

Enzyme Chemistry 1

PC 6-1 to 6-2

Lec12 aft pdf Lecture flash

Q2, E2

 

Lec 13

M

6 Oct

Enzyme Chemistry 2

PC 6-3 to 6-4

Lec13 aft pdf Lecture flash

Q2, E2

TA sessions

Quiz 2 study guide pdf

Lec 14

W

8 Oct

Quiz 2, Enzymes: Kinetics 1

PC 7-1

Lec14 aft pdf Lecture flash

E2

 

Lec 15

F

10 Oct

Enzymes: Kinetics 2

PC 7-2

Lec15 aft pdf Lecture flash

E2

Quiz 2 average was 18

StDev 2.8 Good job!

 

M

13 Oct

Holiday

 

 

 

Columbus Day

Lec 16

Tu

14 Oct

Enzymes: Kinetics 3

PC 7-3

Lec16 aft pdf Lecture flash E2

Monday schedule

Lec 17

W

15 Oct

Carbohydrates

PC 11-1 to 11-2

Lec17 aft pdf Lecture flash

E2

Last day to Drop with ‘W’

Rev

F

17 Oct

Review and Problems

 

Rev pdf Study guide pdf

E2

Ch11 study guide pdf.

 

M

20 Oct

Exam 2: 7-9pm

Mahar 108

Make-ups held during class period*

TA session Goessmann 64 during class time

 

Exam 2 average was 75

StDev 13

Lec 18

W

22 Oct

Intro to Biological membranes. Lipids

PC Chp 8.1 pp 220-227

Advanced reading lipids pdf

Lec18 aft pdf Lecture flash

Challenge text

E3 Q3

The fluid mosaic model original paper pdf

Lec 19

F

24 Oct

The lipid bilayer.

PC 8.2 pp 227-230

Advanced reading PS pdf

Lec 19 after pdf Lecture flash

E3 Q3

Exam 2 key

Study guide 1 Ch 8 pdf key

Lec 20

M

27 Oct

Membrane proteins. The fluid mosaic model. Movie file. FRAP file

PC 8.3-4 pp 230-234

Lec 20 after pdf Lecture flash

E3 Q3

Lectures 18-21

Lec 21

W

29 Oct

Membrane transport

PC Ch 9.1-9.3 pp 241-255 Advanced reading on Omega-3s fatty acids link

Lec 21 after pdf Lecture flash

E3 Q3

Study guide 2 Quiz 3. Chapters 8-9 pdf

Lec 22

F

31 Oct

Quiz 3,Metabolism and Bioenergetics

PC Ch 12.1-12.2 pp 308-322

Lec22 aft pdf Lecture flash

E3

Ch12 Study guide 3 pdf

Lec 23

M

3 Nov

Metabolic reactions and free energy changes. Glucolysis

PC Ch 12.3 pp 323-331 Ch 13.1 pp 338-343

Lec 23 after pdf Lecture flash

 

E3

Quiz 3 key

Quiz 3 average was 16.2

StDev 3.2

Lec 24

W

5 Nov

Glucolysis. (The fate of pyruvate.)

Gluconeogenesis.

PC Ch 13.1-13.2 pp 343-357

Lec 24 after pdf Lecture flash

Thursday TA session

E3

Study guide 4 The fate of pyruvate pdf. Key

Rev

F

7 Nov

Review

 

Rev pdf

E3

Old Exam 3 example pdf key

 

M

10 Nov

Exam 3: 7-9pm Thom 104

Bring calculator (no phones allowed).

Ch 8, 9, 12, and 13 as covered in class.

 

 

TA session in class time

 

W

12 Nov

Holiday

 

 

 

Veteran's Day

Lec 25

F

14 Nov

The pentose Phosphate Pathway

PC Ch 13.4 pp 361-364

Advanced reading on metabolism pdf.

Lec 25 after pdf Lecture flash

E4 Q4

Exam 3 key

Exam 3 averg 86 Stdev 11

Lec 26

M

17 Nov

The cytric acid cycle (CAC)

PC Ch 14 pp 370-380

Lec 26 after pdf Lecture flash

 

E4 Q4

Study guide pdf.Cytric acid cycle Key

Lec 26

W

19 Nov

Finish CAC. Oxidative phosphorylation

 

PC Ch 14-15.1 pp 380-398

Advanced reading on Citric Acid Cycle pdf

Lec 27 after pdf Lecture flash

 

 

E4 Q4

Study guide pdf. Oxidative phosphoriration Key

Practice Q4 and key

Lec 28

F

21 Nov

Oxidative phosphorylation

PC Ch 15.2 pp398-408

 

Lec 28 after pdf Lecture flash

 

E4 Q4

Study guide pdf. Oxidative phosphorilation2 Key

Lec 29

M

24 Nov

Quiz 4, Chemiosmosis.ATP synthase

PC Ch 15.3-4 pp408-414

Lec 29 after pdf Lecture flash

E4

Study guide pdf. ATPsynthase Key

 

W

26 Nov

No class

Read review on ATPase pdf

Do not forget homeworks!

 

 

 

 

F

28 Nov

Holiday

 

 

 

 

Happy Thanksgiving!

Lec 30

M

1 Dec

Mechanism of the F1F0-type ATP synthase paper

Capaldi & Aggeler 2002

Movies link

 

Lec 30 after pdf Lecture flash

 

E4

Quiz 4 key Average 16.0

Stdev 4.2

Lec 31

W

3 Dec

Review 2 Practice Exam4 pdf

Key

 

Exam 4 prep notes pdf

Lec 31 after pdf Lecture flash

 

E4

Homework average was 112, stdev 17 (Total 120)

 

F

5 Dec

Exam 4: 7-9 PM Mahar 108

Study hard!

TA session in class time

Study hard!

Exam 4 average was 69

stdev 15

Exam 4 key

Office hours

Th

11 Dec

No exam in final's week

3:30PM Lederle GRT 1228

Pick up your exams

 

Course average over 600 total points was: 83 stdev 9

*Make-up exams must be arranged in advance.