Chem/Biochem 657: Drug Design Spring 15
T&Th 1:00pm
ISB 329

Instructors:   Jeanne A. Hardy (hardy@chem.umass.edu, 745A Lederle Tower, 5-3486)
  Scott C. Garman (garman@biochem.umass.edu, 1021K Lederle Tower, 7-4488)
  UMass Moodle site
Today is
Glossary

 

Date Topic Notes Reading:

required and optional

  Introductory material

Course_syllabus

Plagiarism links

Drug design glossary;

T Jan 20 JAH: Introduction to course; Drug discovery timeline part 1  

 

Th Jan 22 JAH: Introduction to protein-ligand binding  

 

T Jan 27 JAH:  

 

Th Jan 29 SCG: Drug discovery timeline part 2: Lead optimization to clinical trials

 

 

T Feb 3 SCG: Pharmacokinetics and pharmacodynamics

 


Th Feb 5 SCG: Introduction to transmembrane receptors

 

 
 
T Feb 10

Exam 1

 

 

 

Th Feb 12 Meaghan Richmond, AstraZeneca: Patents and intellectual property

 

 

T Feb 17 No class meeting: Monday class schedule    
Th Feb 19

Discussion: Richmond

 

 

T Feb 24

Mark Murcko, Disruptive Biomedical: Cystic fibrosis case study

 


Th Feb 26

Discussion: Murcko

 

 

T Mar 3 Chris Lipinski, Melior Discovery: Reducing lead time

 

 

Th Mar 5

Discussion: Lipinski

   
T Mar 10

Woody Sherman, Schrödinger: Computer-aided drug discovery

 

 

Th Mar 12

Discussion: Sherman

   
  Spring Break    
T Mar 24 Jonathan O'Connell, Forma Therapeutics: High-throughput screening  

 

Th Mar 26

Discussion: O'Connell

   
T Mar 31 Joanna Swain, Bristol-Myers Squibb: Protein pharmaceuticals  

 

Th Apr 2

Ravi Kurumbail, Pfizer: Applications of structure-based drug design

 

T Apr 7

Discussion: Swain

 

 

Th Apr 9

Discussion: Kurumbail

 

 
F Apr 10 Field Trip to Vertex Pharmaceuticals (optional)

Vertex directions

 
T Apr 14

No class

 


Th Apr 16

Discussion: Vertex trip

   
T Apr 21

Thomas Keating, ImmunoGen: Antibody-drug conjugates

   
Th Apr 23

Discussion: Keating

   
T Apr 28

Wrap up

 

 

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